There are many people with high uric acid in life, and diet is only one of the reasons for hyperuricemia. Let me tell you the reasons for high uric acid. Welcome to read!
I. excessive uric acid production
The causes of excessive uric acid production include idiopathic, excessive purine rich diet, vigorous exercise, alcohol consumption, obesity, hypoxanthine guanine phosphoribosyltransferase (HPRT) deficiency, 5-phosphoribosyl-1-pyrophosphate (PRPP) synthase hyperactivity, hemolysis, lymphoproliferative diseases, myeloproliferative diseases, polycythemia vera, psoriasis, Paget's, glycogen storage diseases (UI, IV, VII) Rhabdomyolysis.
II. Reduction of uric acid excretion
The causes of reduced excretion of uric acid include: idiopathic, renal insufficiency, polycystic kidney disease, diabetes, diabetes insipidus, hypertension, starvation ketosis, acidosis (lactic acidosis, diabetic ketoacidosis), lead poisoning, beryllium poisoning, hypothyroidism, parathyroidism, gestational toxicosis, Bart syndrome, Down's syndrome, and megmatosoma.
III. mixed causes (both excessive generation and reduced discharge)
There are mainly glucose-6-phosphatase deficiency, fructose-1-phosphate aldolase deficiency, drinking and shock.
Therefore, there are many causes of gout, but diet also plays a very important role. We suggest that patients with hyperuricemia must strictly control diet, and diet should run through the treatment of hyperuricemia. In our daily diet, we should try to avoid eating high purine foods (animal viscera, shelled seafood, broth, etc.); Try not to use beverages rich in fructose (fruit juice, coke, etc.); Eat less rather than no animal meat such as beef, mutton, pork and fish. You can blanch it before cooking; Meanwhile, smoking and alcohol consumption (especially Baijiu and beer) should be restricted.
High uric acid is a metabolic disease caused by the disorder of purine metabolism in the human body, resulting in the increase of uric acid in the blood. The daily production and excretion of uric acid in the body are about the same. In terms of production, one third is from food, two-thirds is self-contained in the body, and one-third is excreted from the intestine and two-thirds is excreted from the kidney. As long as there is a problem in any of the above ways, it will lead to the increase of uric acid. High uric acid can also cause other diseases.
Long term hyperuricemia, besides repeated gout, leads to persistent inflammation and gouty stones. It also produces serious complications such as kidney stones, hypertension, diabetes, renal failure and ischemic heart disease, especially in modern research, which indicates that it may accelerate tumor progression and increase the risk of death in cancer patients. Unbearable pain, joint injury, loss of function, the harm of complications and so on, even threaten their life safety
Therefore, hyperuricemia must be paid attention to and combined with comprehensive treatment.
The harm of gout is only one step away from uremia!
Do you think gout is just a genetic disease that causes joint swelling and pain? Do you think young people won't get gout at all? absolutely wrong! If young people have a bad diet for a long time, it can also lead to gout. What's more terrible is that gout can lead to renal failure and eventually uremia.
Gout, once known as "rich disease", has been increasing incidence rate in recent years. It has become a common disease in southeastern coastal areas of China. At present, there are about 15 million gout patients in China, and the potential population has reached 120 million. More than 85% of them are men. They are usually seen in men over the age of 40, and now men around the age of 20-30 are also very common.
Arthritis and nephropathy are the main complications of gout. The pain performance of joint diseases has aroused the general concern of gout patients. The concealment of nephropathy makes many gout patients relax their vigilance, and unknowingly makes gout patients enter the ranks of patients with renal failure. Gouty nephropathy is also known as uric acid nephropathy. About 17% to 25% of gout patients die of renal failure. Gouty nephropathy in the past accounted for only 1% of hemodialysis patients, but now the proportion is increasing. Experts predict that in the next 10 years, kidney failure caused by gout and diabetes will account for more than 50% of hemodialysis patients.