Many pregnant women will have the phenomenon of high glycocholic acid in clinical examination. At this time, we should find the cause of high glycocholic acid and seek the help of doctors. Today, I will share with you the reasons for the high level of glycocholic acid for your reference only!
Serum glycocholic acid is one of the sensitive indexes to evaluate the function of hepatocytes and the circulation function of hepatobiliary materials. High glycocholic acid must be paid attention to, because it may indicate abnormal liver function. Specific reasons generally include the following:
1. Normal physiological phenomenon. During pregnancy, the serum bile acid of normal pregnant women is gradually dominated by glycocholic acid, so the serum glycocholic acid level is higher during pregnancy, and gradually increases with the gestational week.
2. The damage of hepatocytes leads to the high level of glycocholic acid caused by the damage of liver function. When hepatocytes are damaged, the ability of hepatocytes to absorb glycocholic acid decreases, resulting in the increase of glycocholic acid content in blood. It is common in acute hepatitis, chronic active hepatitis, obstructive liver disease, etc.
3. The serum glycocholic acid of patients with intrahepatic cholestasis of pregnancy is significantly higher than that of normal pregnant women, even up to 10-100 times.
Daily diet should pay attention to light, eat more foods with high protein and high fiber, and don't eat fried, pickled and stimulating foods, especially strict abstinence. Pay attention to rest, don't stay up late, don't overwork, take moderate exercise and enhance physical resistance. High side patients must go to the hospital for examination in time to determine the cause, and then take symptomatic treatment measures to avoid deterioration.
1. Vegetables. Spinach is rich in iron and is regarded as one of the vegetables that can prevent anemia during pregnancy. Cauliflower has many benefits. It is rich in calcium and folic acid, has a lot of fiber and disease resistant antioxidants, and contributes to the absorption of iron in other green vegetables
2. Whole wheat products, including cereal porridge, whole wheat biscuits, whole wheat bread, etc. Cereal can make pregnant women with high glycocholic acid maintain more energy and reduce the level of cholesterol in the body
3. Fruits. Eat strawberries, citrus fruits, watermelon, papaya, mango and grapes. They are rich in vitamins C and a, which can help pregnant women with high glycocholic acid maintain physical strength and prevent fatigue caused by water shortage. At the same time, it will also have a certain effect on reducing glycocholic acid
4. Milk and bean products. Pregnant women with high glycocholic acid should consume about 1000 mg of calcium a day, and only three cups of skimmed milk can meet this demand. Yogurt is also rich in calcium and protein, which contributes to gastrointestinal health.
5. Raisins. Raisins contain high relative contents of calcium, phosphorus and iron, and a large amount of vitamins and amino acids. They are a good tonic for pregnant women with high glycocholic acid and those with weak anemia.
The normal metabolic pathway of CG is intestinal hepatic circulation. CG is synthesized by hepatocytes, discharged into the gallbladder through capillary bile duct and bile duct, and enters the duodenum with bile to help food digestion. 95% cholic acid is reabsorbed at the end of ileum, and then returned to the liver through portal vein, which is taken up and reused by hepatocytes. It mainly exists in the form of protein binding in serum, and the total amount of overflow into systemic circulation is less than 1%. Under normal circumstances, the content of cholic acid in peripheral blood is very small. The serum CG concentration of normal adults is stable at a low level whether fasting or after meal.
When hepatocytes are damaged, the ability of hepatocytes to absorb CG decreases, resulting in the increase of CG content in blood; During cholestasis, the liver excretes cholic acid, and the content of CG in reflux blood circulation increases, which also increases the content of blood CG. Therefore, the determination of serum glycocholic acid (SCG) by RIA (radioimmunoassay) is one of the sensitive indexes to evaluate the function of hepatocytes and the circulatory function of hepatobiliary substances.
The content of serum glycocholic acid in normal subjects: 1.3 ± 0.8mg/l, ranging from 0.4 to 2.98mg/l. The lower limit of hepatitis diagnosis is < 3.18mg/l.
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