Many people have more or less liver injury. There are many reasons for liver injury. We should pay more attention to protecting the liver in our daily life. The following is the content about the causes of liver injury sorted out by me, which can be provided for your reference and understanding!
1. Liver damage caused by other diseases: primary and secondary liver tumors, liver congestion caused by cardiac insufficiency, some congenital liver diseases, high-priced intravenous nutrition, etc. can cause varying degrees of liver damage. The early manifestation of these liver damage is often the increase of ALT (transaminase) or bilirubin. Without removing the cause, the liver damage will be further aggravated.
2. Unclean diet aggravates the burden on the liver: unclean diet leads to disease from the mouth. Unsanitary food will not only stimulate the intestinal tract, cause vomiting and diarrhea, but also increase the burden on the liver.
3. Staying up late makes it difficult to repair the damaged liver: busy work, irregular life, often staying up late and lack of sleep will cause a relative lack of blood flow in the liver, affect the nutrition and moisture of liver cells and reduce resistance. Some people's damaged hepatocytes will be difficult to repair and worsen. 4. Dirty environment damages the liver: air pollution and deterioration of living environment are problems that modern people have to face. Especially in cities, the air circulation speed is slow, and all kinds of industrial waste gas and automobile exhaust fill the air with all kinds of chemical poisons, damaging the liver and health.
5, viral infection causes liver damage: liver injury is caused by many hepatitis viruses, characterized by strong infection, complex transmission routes, widespread epidemic and high incidence rate. At present, viral hepatitis is mainly divided into five types: hepatitis A, hepatitis B, hepatitis C, hepatitis D and hepatitis E. hepatitis B and hepatitis G have been found in recent years.
6. Alcohol is a great threat to the liver: long-term or intermittent heavy drinking can cause liver injury. The greater the amount of drinking and the longer the duration of drinking, the more serious the consequences. Alcohol will directly poison hepatocytes and affect their structure and function. Traditional Chinese medicine believes that "wine is hot food and damages liver yin". Even drinking a lot of iced beer in summer will cause damage to the liver.
Drug induced hepatitis focuses on prevention, and the following points should be paid attention to:
1. During drug treatment, especially when treated with new drugs, each patient should pay attention to monitoring the adverse reactions of various drugs, and regularly measure blood and urine routine and liver and kidney functions.
2. Special attention should be paid to patients with previous drug allergy history or allergic constitution.
3. For patients with liver and kidney disease, newborns and those with nutritional disorders, the dosage of drugs should be cautious.
4. In case of abnormal liver function or jaundice, the treatment should be terminated.
5. Those with a history of drug-induced liver damage should avoid taking drugs with the same or similar chemical structure.
Common drugs that hurt the liver most:
Anti tuberculosis drugs: rifampicin, isoniazid, ethambutol, etc;
Antitumor drugs: cyclophosphamide, methotrexate, 5-fluorouracil, carboplatin, cisplatin, etc;
Lowering blood lipids: statins (atorvastatin, lovastatin), fenofibrate, clofibrate, niacin, etc;
Steroid hormones: estrogen drugs, oral contraceptives, androgen assimilation, etc;
Cardiovascular drugs: Amiodarone, warfarin, calcium antagonists, etc;
Indomethacin, indomethacin, etc;
Antibiotics: chloramphenicol, roxithromycin, ketoconazole, penicillins, sulfonamides, etc;
Anti allergic drugs: promethazine (phenergan), chlorphenamine (chlorphenamine), loratadine (kairuitan), etc;
Anti ulcer drugs: cimetidine, ranitidine, famotidine, etc;
Medicine for treating fever: baifuning
Antifungal drug: dakenin (oral)
Traditional Chinese medicine: Compound Traditional Chinese medicine for the treatment of malignant tumors, hysteromyoma, skin diseases and for stone removal and weight loss (mainly including huangyaozi, Xanthium sibiricum, toosendan, Tripterygium wilfordii, Guanzhong, etc.).
(I) true liver laceration
Slight injury has less bleeding and can stop by itself, and the abdominal signs are also light. Severe injury, massive bleeding and shock. The patient's face was pale, his hands and feet were cold, he sweated cold, his pulse was slow, and then his blood pressure decreased. If combined with bile duct rupture, bile and blood stimulate the peritoneum, causing abdominal pain, abdominal muscle tension, tenderness and rebound pain. Sometimes bile sweat stimulates the diaphragm, resulting in hiccup and shoulder pain.
(II) hepatic subcapsular laceration
Most of them have subcapsular hematoma. When the injury is not serious, the clinical manifestations are not typical. Only the liver area or right upper abdomen is swollen and painful, the right upper abdomen is tender, the liver area is percussive and painful, and sometimes the liver with tenderness can be touched. There was no hemorrhagic shock and obvious peritoneal irritation. If secondary infection, it will form an abscess. Due to continuous bleeding, the subcapsular hematoma gradually increases and the tension increases. It can rupture after several hours or days, and a series of symptoms and signs of true liver laceration appear.
(III) central hepatic laceration
Hematoma is formed in the deep part, and the symptoms are not typical. Sometimes, there is rupture of intrahepatic bile duct, blood flows into bile duct and duodenum, manifested as paroxysmal biliary colic and upper gastrointestinal bleeding.
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