Many people have liver function tests, which show that the total bilirubin is high. What causes bilirubin to be on the high side? How to treat bilirubin on the high side? The following is the reason and treatment of high bilirubin I sorted out for you. I hope it will be useful to you!
The life span of human red blood cells is generally 120 days. After the death of red blood cells, they become indirect bilirubin, which is transformed into direct bilirubin through the liver to form bile, which is discharged into the bile duct and finally discharged through stool. The sum of indirect bilirubin and direct bilirubin is total bilirubin. Obstacles in any of the above links can cause jaundice.
If there is too much destruction of red blood cells and too much indirect bilirubin, and the liver can not completely convert it into direct bilirubin, hemolytic jaundice can occur; When the liver cell has pathological changes, because bilirubin cannot be transformed into bile normally, or because the liver cell is swollen, the bile duct in the liver is compressed, the excretion of bile is blocked, and the bilirubin in the blood is increased, then the liver cell jaundice occurs; Once tumors or stones occur in the extrahepatic biliary system, the biliary tract will be blocked, and the bile can not be excreted smoothly, resulting in obstructive jaundice. The jaundice of patients with hepatitis is generally hepatocyte jaundice, and the direct bilirubin and indirect bilirubin are increased, while the direct bilirubin is mainly increased in patients with cholestatic hepatitis.
1. High direct bilirubin. If hepatocytes are damaged, bilirubin cannot be converted into bile normally, or bile excretion is blocked, it will lead to high direct bilirubin. The common causes of high direct bilirubin include intrahepatic and extrahepatic obstructive jaundice, pancreatic head cancer, bile capillary hepatitis and other bile stasis syndrome.
2. Total bilirubin, direct bilirubin and indirect bilirubin are increased: acute icteric hepatitis, chronic active hepatitis, cirrhosis, toxic hepatitis, etc.
3. Increase of total bilirubin and direct bilirubin: intrahepatic and extrahepatic obstructive jaundice, pancreatic head cancer, bile capillary hepatitis and other bile stasis syndrome.
4. Increase of total bilirubin and indirect bilirubin: hemolytic anemia, blood group incompatibility, blood transfusion, malignant diseases, neonatal jaundice, etc.
5, red blood cells rupture factors: liver damage, can cause hepatitis B patients in the liver of a large number of red cell death and rupture, when the liver metabolism function is not enough to make it converted to direct bilirubin, can cause hemolytic jaundice symptoms.
6, hepatocyte lesion factors: when hepatitis B patients in vivo liver cells lesions, or bilirubin can not be converted to bile, can cause liver enlargement, intrahepatic bile duct is oppressed and cause bile excretion damage, cause blood bilirubin content increase.
7, bile blockage factors: for example, hepatitis B patients suffering from gallstones, cholelithiasis can block the excretion of bile in the liver, so that the bile can not be successfully excluded from the liver, which can also lead to increased bilirubin in the blood.
Step 1: find out the cause of high bilirubin
In the face of high bilirubin, we first need to understand whether it is caused by liver disease. Therefore, a comprehensive liver examination is needed.
Step 2: according to the etiology, symptomatic treatment
If the bilirubin is elevated in patients with hepatitis B, it may be because the liver cells are attacked by hepatitis B virus and cause liver damage, which can not transform indirect bilirubin, which results in the increase of direct bilirubin. This requires killing and removing the virus from the hepatitis B virus.
Step 3: reasonable diet to promote recovery
For patients with liver disease, the reason for high bilirubin is usually abnormal liver function. Therefore, the diet of patients with high bilirubin should be light, nutritious and easy to digest without increasing the burden on the liver. Eat more fresh vegetables and fruits to improve the immune capacity of the human body.
Once the disease is found to be on the high side, the treatment of bilirubin can be improved only by finding the correct cause of the disease.
Most of the bilirubin in the body comes from hemoglobin released by aging red blood cells, including indirect bilirubin and direct bilirubin. Indirect bilirubin is transported to the liver through blood and generates direct bilirubin through the action of hepatocytes. No matter in any organ of heme metabolism, it can make the total bilirubin on the high side and cause jaundice in the human body.
Harm of high total bilirubin: when the total bilirubin in serum is too high, it indicates liver injury or bile duct blockage.
Harm of high indirect bilirubin: if there is too much destruction of red blood cells, too much indirect bilirubin is produced, which exceeds the metabolic range of the liver, and the liver cannot completely convert it into direct bilirubin, hemolytic jaundice will occur.
Harm of high direct bilirubin and indirect bilirubin: jaundice in patients with hepatitis is generally hepatocyte jaundice, that is, both direct bilirubin and indirect bilirubin are increased, while direct bilirubin is mainly increased in patients with cholestatic hepatitis.
Bilirubin can not be transformed into bile normally, hepatocyte disease, hepatocyte swelling, compression of bile duct in the liver or obstruction of bile excretion will increase bilirubin in the blood, and then hepatocyte jaundice will occur; Extrahepatic biliary system has tumors or stones, biliary obstruction, bile can not be excreted smoothly, and then obstructive jaundice occurs. Jaundice in patients with hepatitis is mainly hepatocellular jaundice.